Nice! I like the how you have her eyes looking at the cellphone, it really drives home what is going on. Nice job with the light coming out of the refrigerator. You have a good control over how light reacts to its surroundings.
Completely normal. Absolutely normal. More than normal.
Unless she has terrible pains. That could lessen the mood a bit with it feeling like someone is cramming a freezing cold log through your stomach. No, but really, periods don't just magically make a person act impossible/furious/hysterical. And Harley Quinn? Oh, she definitely would not let any possible change that would or would not exist show at all.
The only thing I dislike is what you did to her headwear. It's a cap attached to the rest of the Harlequin outfit- there's not a part that goes over her face. That's all done with makeup. The headpiece just frames her face. Her black mask and the white face is all oil paints.